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Quit Smoking Aid Flavoured Air Device 🚬🚭

Four days of cannabis treatment stopped breast cancer from spreading.

Researchers exposed miniature, three-dimensional breast tumor models grown from human and mouse cancer cells to low doses of THC, a cannabis compound.

The treated models became less invasive, less able to renew themselves, and less capable of starting tumors.

When transplanted into mice, they produced tumors later, with slower growth and less aggressive features than untreated controls.

The study targeted cancer cell plasticity: the ability to switch between different states. Some cancer cells can become more stem-like, helping them survive treatment and contribute to tumor growth.

Rather than simply killing these cells, researchers tried to stabilize them in a more specialized state that limited this flexibility.

The results pointed mainly to cannabinoid receptor 2, or CB2R, part of the body’s endocannabinoid system. CB1R, the receptor strongly associated with cannabis’ intoxicating effects, did not show the same pattern.

Importantly, a compound that reduced CB2R’s baseline activity reproduced THC’s effects. Mouse-derived tumor models lacking CB2R also showed similar changes. The mechanism therefore appears more complex than simply activating a “cannabis receptor.”

Genetic analyses revealed changes in gene activity and the organization of DNA-associated proteins, consistent with a more stable cell identity.

Treated models also became more sensitive to tamoxifen, a hormone therapy used for certain breast cancers. In a separate mouse experiment, THC-treated cells produced fewer cancer cell clusters in the lungs.

These findings suggest a possible way to make tumors less adaptable and more responsive to treatment. They do not establish that cannabis treats breast cancer in people. Safety and effectiveness still need clinical testing.
Read the study:
“Transient CB2R modulation durably restricts breast cancer plasticity by stabilizing a luminal-like cell identity.” Communications Biology

Recycled Skateboard Chop Bowl 🍃

Made from recycled skateboard decks, each wooden chop bowl features its own vibrant colours and unique patterns. No two are ever the same.

Now Available at Get H**pified !

🌿🎶 You get ONE song to add to the Get H**pified playlist… what’s it gonna be? Drop the title and artist below! 👇

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🥚🌿 Fresh eggs available at Get H**pified!

Our chickens are fed a h**p-infused mixed grain mash. Pop in-store and grab some today, or call ahead to reserve yours for convenient kerbside pickup!

🌿 Mackay Show Week Hours 🌿
We’ll be open Monday 10am–4pm and closed Thursday for Show Day.
Drop in and see us for all your h**p essentials. Have a great Show Week, Mackay! 💚