Herbal Puff Responsibly

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https://www.health.harvard.edu/blog/the-endocannabinoid-system-essential-and-mysterious-202108112569

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Cannabinoids heal and protect the brain 🧠

The anti-excitotoxic, anti-inflammatory and antioxidant effects of cannabinoids modulate neuroplasticity, homeostasis, remyelination, survival, maturation and proliferation of both glial and neuronal cells.

When taking in account all of these factors, cannabinoids are shown to be extremely versatile molecules with neuroprotective and repair capabilities within the central nervous system.

Rodrigues, et. al. (2019) Cannabinoid Actions on Neural Stem Cells: Implications for Pathophysiology. Molecules. https://bit.ly/40lx5Kd

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AGING AND CANNABINOIDS

Aging is a complex phenomenon associated with a wide spectrum of physical and physiological changes affecting every part of all metazoans, if they escape death prior to reaching maturity.

Gero-scientists classify aging into two categories: “Chronological” and “Biological” aging. While chronological aging is a “non-reversible” process, biological aging is a controllable and theoretically reversible process.

Because how significantly immune system affects and is affected by aging, several neologisms now appear to encapsulate these reciprocal relationships, such as Immunosenescence. The central part of Immunosenescence is Inflammaging –a sustained, low-grade, sterile inflammation occurring after reaching reproductive prime.

Inflammaging, a potentially underlying cause for a significant number of age-related diseases, has rationalized anti-inflammatory interventional protocols as therapeutic strategies to slow, limit and/or reverse the adversarial symptoms of aging, closing the gap between increase in lifespan and its lopsided ratio with healthspan.

Given the existing urgency in exploring reliable and effective therapeutic modalities to reverse the aging symptoms and inflammaging, cannabinoids and specifically CBD appear as potential potent compounds to be targeted as part of anti-aging therapeutic regimen.

CBD has shown the most potential as a therapeutic agent in the treatment of inflammatory diseases. This is due to CBD’s non-psychotropic nature, relative safety, low toxicity and its modulatory effects on several pro-inflammatory signals.

Baban, et. al. (2021) Inflammaging and Cannabinoids. Ageing research reviews, 72, 101487. https://doi.org/10.1016/j.arr.2021.101487