MS Support Group.

Source: Neuroscience News

neurosciencenews.com | 502: Bad gateway

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Researchers at Weill Cornell Medicine investigated why multiple sclerosis (MS) may need an environmental trigger in addition to genetic susceptibility. They focused on a bacterial toxin called epsilon toxin (ETX), made by specific toxin-producing strains of Clostridium perfringens that typically inhabit the small intestine.

In a 2023 Journal of Clinical Investigation (JCI) study, the team used high-sensitivity PCR-based detection and found that people with MS were more likely to carry ETX-producing C. perfringens and also showed greater abundance of these toxin-producing strains compared with healthy controls.

The study also characterized the toxin types present. It reported that among ETX-positive samples, type D strains were most common, with fewer type B strains detected, reinforcing that the key signal is ETX-producing toxinotypes (B/D) rather than a single subtype alone.

To test whether ETX could help initiate MS-like disease activity, the researchers used an established MS animal model called experimental autoimmune encephalomyelitis (EAE). In that model, pertussis toxin is often used to help break “immune privilege” of the central nervous system. The team showed that ETX could substitute for pertussis toxin, producing disease patterns that looked more like MS, including inflammatory demyelination across multiple brain regions rather than being largely limited to the spinal cord.

Mechanistically, ETX is notable because it targets CNS blood vessels and is linked with blood–brain barrier disruption and increased immune-cell entry into the brain. Separate experimental work has also described ETX-driven blood–brain barrier permeability pathways, supporting the plausibility of a toxin-mediated route from gut to brain.

This line of evidence strengthens the broader idea of a gut–brain connection in MS, where a microbial product may help start or accelerate neuroinflammation in susceptible individuals. MS organizations have highlighted these findings as a meaningful step toward understanding potential triggers.

This is a very intriguing thought process on healing ... very different from Western medicine

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Here is an organization that could be helpful in your journey to wellness:

https://www.sister-bear.com/

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